Everyone Should Understand the Potential Heart Risk of Psychedelics

An important part of building a healthy psychedelic community is being fully aware of the risks of psychedelics.

This includes both being educated about the risk of trauma and injury from challenging psychedelic experiences, but also the potential physiological harm they can do to us.

It appears that occasional large doses of psychedelics don’t do much harm to healthy individuals, as long as they are properly looked after to prevent really damaging traumatic experiences (sometimes called “Bad Trips”). But we don’t have any evidence yet that regular microdosing is safe.

Continue reading

Psychedelics and Male-Perpetrated Violence

A version of this article was originally published on The Third Wave

WARNING:This article describes violent acts, and links to discussions with hateful violent language.

In April this year, a man drove a van across busy pedestrian streets in Toronto, killing 10 and injuring more. It was the deadliest mass homicide in the city’s history.

The murderer identified himself with the growing “incel” movement – a term with origins in sexual frustration (the word “incel”  is a portmanteau of the misnomer “involuntary celibate”) that has now been appropriated by a nebulous group of disgruntled men who believe that society is rigged against them, dooming them to a life without the sex they’re entitled to.

Mostly confined to online forums, the number of people defining themselves as incels is hard to pin down – although a recent surge in searches for “incel” and the media attention following the Toronto attack suggests that its popularity is on the rise.

The online gathering-places for the modern incel are littered with calls for misogynistic violence, rape, and coercion. When incels aren’t praising the violent actions of mass murderers, or urging others to act in a similar fashion – they’re spreading brutal misogynistic propaganda promoting rape, domestic abuse, and pedophilia.

The reasons behind the surge in incel ideologies are many and complex: harmful patriarchal gender conventions; the normalization of aggression in young boys; the struggle some men encounter in connecting with their emotions. There are dozens of models to explain the attractiveness of incel philosophies to the modern man. But no matter what psychological and societal reasons for incelhood, the movement is inarguably associated with violence.

structure-746577_1280

Male-perpetrated violence is, unsurprisingly, soaked throughout culture and history. It’s not just a phenomenon confined to the bloody sands of ancient battlefields or the slave trade of America and Europe’s shameful legacies. It’s reflected in modern domestic violence statistics, showing that male-perpetrated domestic violence accounts for 91% of all domestic abuse prosecutions, and that 87% of all domestic homicides are perpetrated by men.

There is clearly a very current, prevalent, systemic issue with male-perpetrated violence in society. The incel movement is just another way in which this problem is being highlighted. And we need to do something about it.

Continue reading

New Clues In The Psychedelic Treatment Of Depression

A version of this article was originally published on High Existence, and The Third Wave.

Depression, despite affecting millions worldwide, is still a condition that we don’t fully understand.

In fact, we understand it so poorly that typical pharmaceutical treatments indiscriminately target whole neurochemical systems, resulting in unstable effectiveness and a host of side-effects.

Up to 44% of people suffering from depression have not found relief from typical antidepressant therapies. Even patients who find some form of relief from the usual prescribed antidepressants need frequent doses, sometimes causing unpleasant side-effects, and these drugs often lose their effectiveness after several years of treatment.

But where pharmaceuticals are failing, psychedelics could be a new hope.

Continue reading

LSD for Depression? Absolutely.

I wrote this article for The Third Wave, where it originally appeared, as a response to an opinion piece in the New York Times from skeptical clinical psychiatrist Richard Friedman. I think it can help address the typical arguments that come from people of anti-psychedelic bias. Enjoy!

A recent article in the New York Times, penned by clinical psychiatrist Richard Friedman, attempts to scare his audience into thinking that LSD might not be a good treatment for depression, despite a barrage of recent studies suggesting otherwise. Friedman appears to be of the opinion that it would be wrong to offer these drugs to sufferers of disease; even though there is no evidence of harm from LSD or psilocybin when given in a clinical setting, and despite the growing body of evidence of the efficacy of these drugs in treating mental health conditions.

light-2076781_640

Friedman himself mentions the debilitating nature of depression; between a third and one-half of all patients will never find relief from conventional treatments. Hundreds of millions suffer worldwide, and hundreds of thousands commit suicide every year. Most of those sufferers don’t have access to the expensive treatments most commonly handed out by psychiatrists in the developed world.

Continue reading

Musical Meaning with LSD

This month has been another great one for the psychedelic community; with a highlight being the release of two fascinating papers which take us a step closer to understanding exactly how LSD works in the brain.

I summarise these two articles in more depth here, but for now I wanted to focus on an overlooked part of one of the studies: and it’s to do with music.

laser-show-589727_1280

Most of us are aware that LSD is supposed to enhance your appreciation for music – it’s probably the main thing that attracted me to the substance, and I’m sure at least some people out there are the same. I wanted to be able to appreciate music in a new way, I wanted to experience my favourite sounds in new dimensions and with expanded sensations.

Although I would soon learn that there is a lot more to LSD than letting you see pretty patterns or hear new sounds, there was still a lot of truth in the saying that LSD changes the way you hear music. Songs I’d listened to hundreds of times before had a new depth, a new character… imagine all your favourite songs being re-invented, or refreshed back to their original, first-listen glory.

Continue reading

LSD ‘neurotoxicity’

Call LSD ‘neurotoxic’ in a psychedelic community and see how far that gets you. You’ll probably evoke some laughter, maybe some scorn, but not much else.

For the millions of people who take LSD and similar psychedelics every year, and the tens of millions who have taken LSD since its explosion into mainstream culture in the 1960s, LSD is not a toxic drug. There have been absolutely no documented deaths from LSD overdose; the closest we’ve come was a group of partiers who snorted pure LSD crystal by accident, ingesting thousands of times a normal dose. They suffered some nasty physical effects including diarrhea and seizures, but they all survived. They didn’t even suffer any major psychological difficulties in the years following the event.

brain-damage

The psychological dangers of LSD are another story. Although we’ve moved past the proved-to-be-false scare stories of kids being blinded by the sun or jumping out of windows, psychedelics really do dramatically alter your perception of reality, and can certainly do some harm to your mind if used irresponsibly.

It’s these psychological harms that have been investigated in a recent study looking back at the hundreds of people who were given LSD in hospitals in the 60s and 70s in Denmark.

Continue reading

Can integrated information theory explain the psychedelic experience?

In our last blog post “Are we living in a conscious universe?” we looked at a new theory of consciousness called “integrated information theory”. IIT was developed in an attempt to understand the link between the physical world and our experience of consciousness.

In trying to understand what physical systems give rise to our experience of consciousness, IIT makes a basic assumption; that consciousness is part of the basic fabric of the universe. At first this may sound unscientific… but in fact we assume many fundamental laws in science. In physics we assume a fundamental link between matter and gravity without being able to see examine the link directly. James Maxwell had to assume some fundamental electromagnetic laws to develop a theory of electromagnetic fields. And in a similar way, IIT assumes that consciousness arises from physical systems due to some fundamental laws of the universe.

universe

The details of IIT are complex, and involve quite a bit of computational neuroscience. Overall, the basic idea is that any physical system that contains feedback systems has at least some level of consciousness. IIT predicts that our brains, with their highly connected and complex feedback systems, are highly conscious – which we can confirm from our own experience.

So what does IIT predict about the psychedelic state? What changes in the way that information is organised in our brains during the psychedelic experience, and how does that fit in with IIT’s model of consciousness?

Continue reading

LSD and associative thinking

Earlier this year, researchers at Imperial showed us the first ever detailed images of the brain on LSD. The images showed that LSD massively increased connectivity in the brain, freeing it from its usual boundaries. Now researchers are starting to piece together how LSD breaks down these boundaries of normal consciousness, leading us to an understanding of the workings of the mind.

carhart-harris-2016-mri

MRI scans from Carhart-Harris et al (2016) show how LSD increases brain connectivity

In a recent study from the same UCL group, funded by the psychedelic research charity the Beckley Foundation, researchers looked into how LSD affects our ability to recognise simple objects. The researchers recruited ten participants for their study, almost all of whom were experienced with psychedelic drugs. The subjects attended two experimental sessions: one where they were injected with LSD (40-80μg), and one where they were injected with a placebo. During both placebo and LSD sessions, participants took an object recognition test. They were shown images of simple objects like pieces of clothing or vehicles. As soon as an image appeared, the participants had to name the object as quickly and accurately as they could.

Continue reading

Cluster headaches

We’ve all suffered from the occasional spontaneous headache. If you’ve experienced migraines before, you’ll know they’re a step up from normal headaches – they cause nauseating pain, blind spots in your vision and pain that can last for hours.

Cluster headaches go beyond even the debilitating pain of migraines. Clinically a different type of headache altogether, they are characterised by severe, excruciating pain focused on one side of the head. An episode can last several hours and can reoccur within a short time period, even several times within the same day. Around one in 500 people suffer from cluster headaches, and some report that their headaches are more painful than childbirth.

headache

Because clinicians don’t understand what causes cluster headaches, treating them is difficult. Current treatments are expensive, unpleasant or impractical – such as inhaling from an oxygen tank or frequent injections. Many medicines, especially preventative ones, cause unpleasant side effects including heart problems and gum disease. An estimated 10-20% of sufferers can’t find relief from any typical treatments. But psychedelic drugs may be able to finally provide relief for those unfortunate few.

Continue reading

Turning up the creativity dial

Swirling colours, delirious patterns, groovy rhythms and otherworldly vistas. These are some of the first things that come to mind when we think about psychedelics. The unique fashion and culture of the 1960s was influenced by the popularity of psychedelic drugs like no other time in our history; the colours, patterns and hair-dos of that time stand out like a carnival in our recent timeline.

paisley

Pink Floyd, Jefferson Airplane, The Rolling Stones, The Beatles… the list of bands influenced by psychedelics could go on and on. Aldous Huxley’s works, still hugely influential to this day, are clearly inspired by his experiences with mescaline and LSD. Steve Jobs took LSD in college, and called it “one of the two or three most important things I have done in my life”. The inventor of PCR, a breakthrough biomolecular technique that has revolutionised medical research, said that LSD gave him the intuition that allowed him to make the ground-breaking discovery. Artists and architects, authors and entrepreneurs have been finding inspiration in LSD, mescaline, psilocybin and DMT for decades.

Continue reading