New research shows a link between Salvinorin A and the DMN

The Default Mode Network (DMN) is by now a familiar name in popular psychedelic circles. It’s a collection of brain areas that talk loudly to each other when we’re not doing any focussed tasks – basically when we’re daydreaming, thinking about ourselves, or conceptualising the past or future.

We know two important things about the DMN: it’s overactive in depression, and psychedelics can help to reset it. Studies have shown that classic psychedelics LSD and psilocybin can dramatically reduce the chatter of the DMN during a psychedelic experience, and allow it to re-form itself into a more stable network afterwards – correlating with decreased depressive symptoms.

Salvinorin A, the main psychedelic component of Salvia divinorum, is not at all like these classic psychedelics. While LSD and psilocybin mainly activate 5-HT2A receptors in the brain, and produce highly visual and often introspective psychedelic experiences; Salvinorin A has barely any 5-HT2A activity, instead activating kappa-opioid receptors and sending users on bizarre and often horrifying trips.

I’ve written (and spoken) fairly extensively about the weirdness of Salvia, and what it means for consciousness. Salvia disrupts an area of the brain called the claustrum, and this is correlated with an almost complete dismantling of typical conscious experience. Our usually coherent and coordinated stream of sensory perceptions, understanding of selfhood, and grasp of the concept of time, dissolves into a barely comprehensible array of pure sensation. Existence is literally ripped apart, in a very fundamental and powerful way, which is not seen as often in classic psychedelics.

Now, new research has shown that Salvinorin A is also connected to the DMN. Twelve experienced psychonauts were given doses of Salvinorin A while in an MRI machine, which showed that the unique psychedelic reduced the connectivity of the DMN in a very similar way to LSD and psilocybin.

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