The period in the 1920s and 30s where alcohol was banned nationwide in the US was a volatile time. It led to an explosion of organised crime, hundreds of thousands of moonshine-related injuries and deaths, and only a moderate reduction in the use of alcohol. The US missed out on untold millions of tax dollars in that 13-year period of prohibition – in a particularly tumultuous economic time that included the great depression of 1929.
Few people would argue that prohibition was a good idea. Although it may have reduced liver damage and moderately reduced alcohol consumption, it increased crime, led to thousands of deaths from poisoned alcohol, and unfairly targeted working class Americans. Any benefits from reducing the sale and production of a harmful drug were minor compared to the unintended consequences of criminalisation.